2QKK
Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| F | 0003676 | molecular_function | nucleic acid binding |
| F | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| I | 0003676 | molecular_function | nucleic acid binding |
| I | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| J | 0003676 | molecular_function | nucleic acid binding |
| J | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| M | 0003676 | molecular_function | nucleic acid binding |
| M | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| N | 0003676 | molecular_function | nucleic acid binding |
| N | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| R | 0003676 | molecular_function | nucleic acid binding |
| R | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| S | 0003676 | molecular_function | nucleic acid binding |
| S | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| W | 0003676 | molecular_function | nucleic acid binding |
| W | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1001 |
| Chain | Residue |
| A | ASP145 |
| A | GLU186 |
| A | ASN210 |
| A | CA1002 |
| C | A5 |
| C | C6 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1002 |
| Chain | Residue |
| A | HOH2003 |
| A | HOH2007 |
| C | C6 |
| C | HOH15 |
| A | ASP145 |
| A | ASP274 |
| A | CA1001 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1009 |
| Chain | Residue |
| B | ASP145 |
| B | ASN210 |
| B | ASP274 |
| B | HOH2002 |
| B | HOH2003 |
| B | HOH2004 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 2001 |
| Chain | Residue |
| B | TYR143 |
| F | TYR143 |
| F | PHE267 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA E 1003 |
| Chain | Residue |
| E | ASP145 |
| E | ASP274 |
| G | C6 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA E 1004 |
| Chain | Residue |
| E | ASP145 |
| E | GLU186 |
| E | ASN210 |
| G | A5 |
| G | C6 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA F 1013 |
| Chain | Residue |
| F | ASP145 |
| F | ASN210 |
| F | ASP274 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA I 1006 |
| Chain | Residue |
| I | ASP145 |
| I | ASP274 |
| K | C6 |
| K | HOH26 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA J 1008 |
| Chain | Residue |
| J | ASP145 |
| J | ASN210 |
| J | ASP274 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA M 1010 |
| Chain | Residue |
| M | HOH11 |
| M | HOH12 |
| M | ASP145 |
| M | ASP274 |
| M | CA1014 |
| O | C6 |
| O | HOH15 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA M 1014 |
| Chain | Residue |
| M | ASP145 |
| M | GLU186 |
| M | ASN210 |
| M | CA1010 |
| O | A5 |
| O | C6 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA N 1005 |
| Chain | Residue |
| N | ASP145 |
| N | ASN210 |
| N | ASP274 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA R 1011 |
| Chain | Residue |
| R | ASP145 |
| R | GLY146 |
| R | ASP274 |
| T | C6 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA S 1007 |
| Chain | Residue |
| S | ASP145 |
| S | ASN210 |
| S | ASP274 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA W 1012 |
| Chain | Residue |
| W | ASP145 |
| W | ASN210 |
| W | ASP274 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRS D 2003 |
| Chain | Residue |
| A | GLY266 |
| A | GLU271 |
| A | ASP286 |
| D | DA17 |
| D | HOH2004 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES A 2002 |
| Chain | Residue |
| A | THR219 |
| A | ILE256 |
| A | GLN257 |
| A | TRP258 |
| R | ASN220 |
| R | GLN223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1022 |
| Details | Domain: {"description":"RNase H type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
