2QI4
Crystal structure of protease inhibitor, MIT-2-AD93 in complex with wild type HIV-1 protease
Summary for 2QI4
Entry DOI | 10.2210/pdb2qi4/pdb |
Related | 2QHY 2QHZ 2QI0 2QI1 2QI3 2QI5 2QI6 2QI7 |
Descriptor | Protease, PHOSPHATE ION, N-[(1S,2R)-3-{(1,3-BENZOTHIAZOL-6-YLSULFONYL)[(2S)-2-METHYLBUTYL]AMINO}-1-BENZYL-2-HYDROXYPROPYL]-3-HYDROXYBENZAMIDE, ... (5 entities in total) |
Functional Keywords | drug design, hiv-1 protease, protease inhibitors, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22353.31 |
Authors | Nalam, M.N.L.,Schiffer, C.A. (deposition date: 2007-07-03, release date: 2008-04-22, Last modification date: 2023-08-30) |
Primary citation | Altman, M.D.,Ali, A.,Reddy, G.S.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Chellappan, S.,Kairys, V.,Fernandes, M.X.,Gilson, M.K.,Schiffer, C.A.,Rana, T.M.,Tidor, B. HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J.Am.Chem.Soc., 130:6099-6113, 2008 Cited by PubMed: 18412349DOI: 10.1021/ja076558p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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