2QHM
crystal structure of Chek1 in complex with inhibitor 2a
Summary for 2QHM
Entry DOI | 10.2210/pdb2qhm/pdb |
Related | 2QHN |
Descriptor | Serine/threonine-protein kinase Chk1, (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE (3 entities in total) |
Functional Keywords | chek1, kinase, cell cycle checkpoint, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 37207.49 |
Authors | Yan, Y.,Munshi, S. (deposition date: 2007-07-02, release date: 2008-03-18, Last modification date: 2023-08-30) |
Primary citation | Brnardic, E.J.,Garbaccio, R.M.,Fraley, M.E.,Tasber, E.S.,Steen, J.T.,Arrington, K.L.,Dudkin, V.Y.,Hartman, G.D.,Stirdivant, S.M.,Drakas, B.A.,Rickert, K.,Walsh, E.S.,Hamilton, K.,Buser, C.A.,Hardwick, J.,Tao, W.,Beck, S.C.,Mao, X.,Lobell, R.B.,Sepp-Lorenzino, L.,Yan, Y.,Ikuta, M.,Munshi, S.K.,Kuo, L.C.,Kreatsoulas, C. Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors. Bioorg.Med.Chem.Lett., 17:5989-5994, 2007 Cited by PubMed: 17804227DOI: 10.1016/j.bmcl.2007.07.051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report