2QHC

The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir

Summary for 2QHC

• Entry DOI: 10.2210/pdb2qhc/pdb
• Related: 2Z54
• Descriptor: PROTEASE RETROPEPSIN, BETA-MERCAPTOETHANOL, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total)
• Functional Keywords: hiv protease inhibitors; protease-inhibitor structure; aspartic protease, resistant strain, hydrolase
• Biological source: human immunodeficiency virus 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22308.42

Authors

Brynda, J.,Saskova, K.G.,Kozisek, M.,Lepsik, M.,Machala, L.,Konvalinka, J. (deposition date: 2007-07-02, release date: 2008-07-22, Last modification date: 2023-08-30)

• Primary citation: Saskova, K.G.,Kozisek, M.,Lepsik, M.,Brynda, J.,Rezacova, P.,Vaclavikova, J.,Kagan, R.M.,Machala, L.,Konvalinka, J.; Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.; Protein Sci., 17:1555-1564, 2008; PubMed: 18560011; DOI: 10.1110/ps.036079.108

Experimental method

X-RAY DIFFRACTION (2.802 Å)