2Z54

The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir

Summary for 2Z54

Entry DOI	10.2210/pdb2z54/pdb
Descriptor	HIV-1 Protease, BETA-MERCAPTOETHANOL, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total)
Functional Keywords	complex (aspartic protease-inhibitor), aspartic protease, resistant strain, hydrolase
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains	2
Total formula weight	22280.36
Authors	Brynda, J.,Klara, S.,Kozisek, M.,Lepsik, M.,Machala, L.,Konvalinka, J. (deposition date: 2007-06-28, release date: 2008-07-01, Last modification date: 2023-11-01)
Primary citation	Saskova, K.G.,Kozisek, M.,Lepsik, M.,Brynda, J.,Rezacova, P.,Vaclavikova, J.,Kagan, R.M.,Machala, L.,Konvalinka, J. Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir. Protein Sci., 17:1555-1564, 2008 Cited by PubMed: 18560011 DOI: 10.1110/ps.036079.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation