2QHC
The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10761.7 | 2 | UniProt (P03367) Pfam (PF00077) UniProt (by SIFTS) (Q9J2P7) In PDB | human immunodeficiency virus 1 (HIV-1) | HIV-1 PROTEASE |
| 2 | A, B | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 3 | B | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) | |||
| 4 | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Ala 47 | Ile 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21523.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 785.1 | |
| All* | Total formula weight | 22308.4 |
