2QHC
The Influence of I47A Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir
Summary for 2QHC
Entry DOI | 10.2210/pdb2qhc/pdb |
Related | 2Z54 |
Descriptor | PROTEASE RETROPEPSIN, BETA-MERCAPTOETHANOL, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total) |
Functional Keywords | hiv protease inhibitors; protease-inhibitor structure; aspartic protease, resistant strain, hydrolase |
Biological source | human immunodeficiency virus 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22308.42 |
Authors | Brynda, J.,Saskova, K.G.,Kozisek, M.,Lepsik, M.,Machala, L.,Konvalinka, J. (deposition date: 2007-07-02, release date: 2008-07-22, Last modification date: 2023-08-30) |
Primary citation | Saskova, K.G.,Kozisek, M.,Lepsik, M.,Brynda, J.,Rezacova, P.,Vaclavikova, J.,Kagan, R.M.,Machala, L.,Konvalinka, J. Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir. Protein Sci., 17:1555-1564, 2008 Cited by PubMed: 18560011DOI: 10.1110/ps.036079.108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.802 Å) |
Structure validation
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