2QFX

Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADPH, a-ketoglutarate and Ca(2+)

2QFX の概要

• エントリーDOI: 10.2210/pdb2qfx/pdb
• 関連するPDBエントリー: 2QFV 2QFW 2QFY
• 分子名称: Isocitrate dehydrogenase [NADP], CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: rossmann fold, oxidoreductase
• 由来する生物種: Saccharomyces cerevisiae (yeast)
• 細胞内の位置: Mitochondrion: P21954
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 294448.10

構造登録者

Peng, Y.J.,Ding, J.P. (登録日: 2007-06-28, 公開日: 2008-07-01, 最終更新日: 2023-11-15)

• 主引用文献: Peng, Y.J.,Zhong, C.,Huang, W.,Ding, J.P.; Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction; Protein Sci., 17:1542-1554, 2008; PubMed: 18552125; DOI: 10.1110/ps.035675.108

実験手法

X-RAY DIFFRACTION (2.7 Å)