2QE2
Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor
Summary for 2QE2
Entry DOI | 10.2210/pdb2qe2/pdb |
Related | 2QE5 |
Descriptor | RNA-directed RNA polymerase, 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID (2 entities in total) |
Functional Keywords | transferase |
Biological source | Hepatitis C virus subtype 1b |
Total number of polymer chains | 2 |
Total formula weight | 129224.71 |
Authors | Chopra, R.,Svenson, K.,Bard, J. (deposition date: 2007-06-22, release date: 2007-10-02, Last modification date: 2023-08-30) |
Primary citation | Nittoli, T.,Curran, K.,Insaf, S.,DiGrandi, M.,Orlowski, M.,Chopra, R.,Agarwal, A.,Howe, A.Y.M.,Prashad, A.,Brawner Floyd, M.,Johnson, B.,Sutherland, A.,Wheless, K.,Feld, B.,O'Connell, J.,Mansour, T.S.,Bloom, J. Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase J.Med.Chem., 50:2108-2116, 2007 Cited by PubMed: 17402724DOI: 10.1021/jm061428x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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