2QD7
HIV-1 Protease Mutant V82A with potent Antiviral inhibitor GRL-98065
Summary for 2QD7
Entry DOI | 10.2210/pdb2qd7/pdb |
Related | 2QCI 2QD6 2QD8 2Z4O |
Descriptor | Protease, PHOSPHATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | hiv-1 protease mutant v82a, protease inhibitor, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22532.30 |
Authors | Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. (deposition date: 2007-06-20, release date: 2008-04-22, Last modification date: 2023-10-25) |
Primary citation | Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50:4509-4515, 2007 Cited by PubMed: 17696515DOI: 10.1021/jm070482q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.11 Å) |
Structure validation
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