2Q7M
Crystal structure of human FLAP with MK-591
Summary for 2Q7M
Entry DOI | 10.2210/pdb2q7m/pdb |
Related | 2Q7R |
Descriptor | Arachidonate 5-lipoxygenase-activating protein, 3-[3-(TERT-BUTYLTHIO)-1-(4-CHLOROBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID (2 entities in total) |
Functional Keywords | mapeg, membrane protein, flap, lipid transport |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus membrane; Multi-pass membrane protein: P20292 |
Total number of polymer chains | 6 |
Total formula weight | 112194.49 |
Authors | Ferguson, A.D. (deposition date: 2007-06-07, release date: 2007-08-21, Last modification date: 2024-02-21) |
Primary citation | Ferguson, A.D.,McKeever, B.M.,Xu, S.,Wisniewski, D.,Miller, D.K.,Yamin, T.T.,Spencer, R.H.,Chu, L.,Ujjainwalla, F.,Cunningham, B.R.,Evans, J.F.,Becker, J.W. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science, 317:510-512, 2007 Cited by PubMed: 17600184DOI: 10.1126/science.1144346 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.25 Å) |
Structure validation
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