2Q7M
Crystal structure of human FLAP with MK-591
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Arachidonate 5-lipoxygenase-activating protein | polymer | 161 | 18111.9 | 6 | UniProt (P20292) Pfam (PF01124) In PDB | Homo sapiens (human) | FLAP, MK-886-binding protein |
| 2 | A, C, D, E | 3-[3-(TERT-BUTYLTHIO)-1-(4-CHLOROBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID | non-polymer | 587.2 | 6 | Chemie (2CS) |
Sequence modifications
A, B, C, D, E, F: 1 - 161 (UniProt: P20292)
| PDB | External Database | Details |
|---|---|---|
| Ala 148 | Lys 148 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 108671.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3523.0 | |
| All* | Total formula weight | 112194.5 |
