2Q5S

Crystal Structure of PPARgamma bound to partial agonist nTZDpa

Summary for 2Q5S

• Entry DOI: 10.2210/pdb2q5s/pdb
• Related: 2Q59 2Q5P 2Q61 2Q6R 2Q6S
• Descriptor: Peroxisome Proliferator-Activated Receptor gamma, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: protein-ligand complex, ligand binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 63447.29

Authors

Bruning, J.B.,Nettles, K.W. (deposition date: 2007-06-01, release date: 2007-10-23, Last modification date: 2023-08-30)

• Primary citation: Bruning, J.B.,Chalmers, M.J.,Prasad, S.,Busby, S.A.,Kamenecka, T.M.,He, Y.,Nettles, K.W.,Griffin, P.R.; Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism; Structure, 15:1258-1271, 2007; PubMed: 17937915; DOI: 10.1016/j.str.2007.07.014

Experimental method

X-RAY DIFFRACTION (2.05 Å)