2Q5K

Crystal structure of lopinavir bound to wild type HIV-1 protease

2Q5K の概要

• エントリーDOI: 10.2210/pdb2q5k/pdb
• 関連するPDBエントリー: 2Q54 2Q55
• 分子名称: Protease, PHOSPHATE ION, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total)
• 機能のキーワード: drug design, hiv-1 protease, protease inhibitors, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22640.26

構造登録者

Schiffer, C.A.,Nalam, M.N.L. (登録日: 2007-06-01, 公開日: 2007-09-04, 最終更新日: 2024-03-13)

• 主引用文献: Reddy, G.S.,Ali, A.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Nathans, R.S.,Schiffer, C.A.,Rana, T.M.; Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres.; J.Med.Chem., 50:4316-4328, 2007; PubMed: 17696512; DOI: 10.1021/jm070284z

実験手法

X-RAY DIFFRACTION (1.95 Å)