2Q54

Crystal structure of KB73 bound to HIV-1 protease

Summary for 2Q54

Entry DOI	10.2210/pdb2q54/pdb
Related	2Q55
Descriptor	Protease, PHOSPHATE ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	drug design, hiv-1 protease, protease inhibitors, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22596.38
Authors	Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-05-31, release date: 2007-09-04, Last modification date: 2024-03-13)
Primary citation	Reddy, G.S.,Ali, A.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Nathans, R.S.,Schiffer, C.A.,Rana, T.M. Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres. J.Med.Chem., 50:4316-4328, 2007 Cited by PubMed: 17696512 DOI: 10.1021/jm070284z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation