2Q5K
Crystal structure of lopinavir bound to wild type HIV-1 protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10815.8 | 2 | UniProt (O38732) UniProt (by SIFTS) (O38710) | Human immunodeficiency virus 1 | |
| 2 | C, D, E, G (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) PubChem (1061) | |||
| 3 | F (A) | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) PubChem (17753816) PubChem (3817) PubChem (46930986) PubChem (52987589) PubChem (44402181) PubChem (44585174) PubChem (45357371) PubChem (59651326) PubChem (46782073) PubChem (60039264) PubChem (76968402) PubChem (66509096) PubChem (86574898) PubChem (68490226) PubChem (92727) PubChem (70829193) PubChem (6540554) PubChem (124349221) PubChem (93971976) PubChem (6850809) PubChem (124349222) PubChem (124349223) PubChem (169442991) PubChem (129168894) PubChem (133109001) PubChem (155002926) PubChem (171370625) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: O38732)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21631.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1008.7 | |
| All* | Total formula weight | 22640.3 |
