2Q5K
Crystal structure of lopinavir bound to wild type HIV-1 protease
Summary for 2Q5K
Entry DOI | 10.2210/pdb2q5k/pdb |
Related | 2Q54 2Q55 |
Descriptor | Protease, PHOSPHATE ION, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total) |
Functional Keywords | drug design, hiv-1 protease, protease inhibitors, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22640.26 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-06-01, release date: 2007-09-04, Last modification date: 2024-03-13) |
Primary citation | Reddy, G.S.,Ali, A.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Nathans, R.S.,Schiffer, C.A.,Rana, T.M. Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres. J.Med.Chem., 50:4316-4328, 2007 Cited by PubMed: 17696512DOI: 10.1021/jm070284z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report