Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2Q5K

Crystal structure of lopinavir bound to wild type HIV-1 protease

Summary for 2Q5K
Entry DOI10.2210/pdb2q5k/pdb
Related2Q54 2Q55
DescriptorProtease, PHOSPHATE ION, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total)
Functional Keywordsdrug design, hiv-1 protease, protease inhibitors, hydrolase
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22640.26
Authors
Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-06-01, release date: 2007-09-04, Last modification date: 2024-03-13)
Primary citationReddy, G.S.,Ali, A.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Nathans, R.S.,Schiffer, C.A.,Rana, T.M.
Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres.
J.Med.Chem., 50:4316-4328, 2007
Cited by
PubMed: 17696512
DOI: 10.1021/jm070284z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon