2Q4G

Ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease I

Summary for 2Q4G

Entry DOI	10.2210/pdb2q4g/pdb
Descriptor	Ribonuclease pancreatic, Ribonuclease inhibitor, CITRIC ACID, ... (4 entities in total)
Functional Keywords	ensemble refinement, refinement methodology development, ribonuclease-inhibitor complex, leucine-rich repeat, enzyme-inhibitor complex, structural genomics, protein structure initiative, psi, center for eukaryotic structural genomics, cesg, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P07998 Cytoplasm: P13489
Total number of polymer chains	4
Total formula weight	129686.03
Authors	Levin, E.J.,Kondrashov, D.A.,Wesenberg, G.E.,Phillips Jr., G.N.,Center for Eukaryotic Structural Genomics (CESG) (deposition date: 2007-05-31, release date: 2007-06-19, Last modification date: 2023-08-30)
Primary citation	Johnson, R.J.,McCoy, J.G.,Bingman, C.A.,Phillips Jr., G.N.,Raines, R.T. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. J.Mol.Biol., 368:434-449, 2007 Cited by PubMed: 17350650 DOI: 10.1016/j.jmb.2007.02.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.954 Å)

Structure validation