2Q4G

Ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease I

Functional Information from GO Data

Chain	GOid	namespace	contents
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005886	cellular_component	plasma membrane
W	0006402	biological_process	mRNA catabolic process
W	0008428	molecular_function	ribonuclease inhibitor activity
W	0016477	biological_process	cell migration
W	0030027	cellular_component	lamellipodium
W	0032311	cellular_component	angiogenin-PRI complex
W	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
W	0036416	biological_process	tRNA stabilization
W	0045765	biological_process	regulation of angiogenesis
W	0070062	cellular_component	extracellular exosome
X	0003676	molecular_function	nucleic acid binding
X	0004519	molecular_function	endonuclease activity
X	0004522	molecular_function	ribonuclease A activity
X	0004540	molecular_function	RNA nuclease activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0016829	molecular_function	lyase activity
X	0050830	biological_process	defense response to Gram-positive bacterium
X	0051607	biological_process	defense response to virus
X	0070062	cellular_component	extracellular exosome
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005886	cellular_component	plasma membrane
Y	0006402	biological_process	mRNA catabolic process
Y	0008428	molecular_function	ribonuclease inhibitor activity
Y	0016477	biological_process	cell migration
Y	0030027	cellular_component	lamellipodium
Y	0032311	cellular_component	angiogenin-PRI complex
Y	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
Y	0036416	biological_process	tRNA stabilization
Y	0045765	biological_process	regulation of angiogenesis
Y	0070062	cellular_component	extracellular exosome
Z	0003676	molecular_function	nucleic acid binding
Z	0004519	molecular_function	endonuclease activity
Z	0004522	molecular_function	ribonuclease A activity
Z	0004540	molecular_function	RNA nuclease activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0016829	molecular_function	lyase activity
Z	0050830	biological_process	defense response to Gram-positive bacterium
Z	0051607	biological_process	defense response to virus
Z	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CIT X 900

Chain	Residue
W	ASP435
X	HOH952
W	SER460
W	HOH519
X	ARG4
X	LYS7
X	GLN11
X	LYS41
X	VAL118
X	HIS119

---

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
X	CYS40-PHE46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
W	SER1
Y	SER1

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
W	THR81
Y	THR81

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
W	SER90
Z	ARG85
Y	SER90
X	LYS41
X	LYS66
X	ARG85
Z	LYS7
Z	ARG10
Z	LYS41
Z	LYS66

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:3202829

Chain	Residue	Details
X	ASN34
Z	ASN34

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3202829

Chain	Residue	Details
X	ASN76
X	ASN88
Z	ASN76
Z	ASN88

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
X	PHE120
X	HIS119
X	HIS12
X	LYS41

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
Z	PHE120
Z	HIS119
Z	HIS12
Z	LYS41

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
X	HIS119
X	HIS12
X	LYS41

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
Z	HIS119
Z	HIS12
Z	LYS41

---