2Q4G
Ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| W | 0005515 | molecular_function | protein binding |
| W | 0005654 | cellular_component | nucleoplasm |
| W | 0005737 | cellular_component | cytoplasm |
| W | 0005829 | cellular_component | cytosol |
| W | 0005886 | cellular_component | plasma membrane |
| W | 0006402 | biological_process | mRNA catabolic process |
| W | 0008428 | molecular_function | ribonuclease inhibitor activity |
| W | 0016477 | biological_process | cell migration |
| W | 0030027 | cellular_component | lamellipodium |
| W | 0032311 | cellular_component | angiogenin-PRI complex |
| W | 0034315 | biological_process | regulation of Arp2/3 complex-mediated actin nucleation |
| W | 0045765 | biological_process | regulation of angiogenesis |
| W | 0070062 | cellular_component | extracellular exosome |
| X | 0003676 | molecular_function | nucleic acid binding |
| X | 0004519 | molecular_function | endonuclease activity |
| X | 0004522 | molecular_function | ribonuclease A activity |
| X | 0004540 | molecular_function | RNA nuclease activity |
| X | 0005515 | molecular_function | protein binding |
| X | 0005576 | cellular_component | extracellular region |
| X | 0016829 | molecular_function | lyase activity |
| X | 0050830 | biological_process | defense response to Gram-positive bacterium |
| X | 0051607 | biological_process | defense response to virus |
| X | 0070062 | cellular_component | extracellular exosome |
| Y | 0005515 | molecular_function | protein binding |
| Y | 0005654 | cellular_component | nucleoplasm |
| Y | 0005737 | cellular_component | cytoplasm |
| Y | 0005829 | cellular_component | cytosol |
| Y | 0005886 | cellular_component | plasma membrane |
| Y | 0006402 | biological_process | mRNA catabolic process |
| Y | 0008428 | molecular_function | ribonuclease inhibitor activity |
| Y | 0016477 | biological_process | cell migration |
| Y | 0030027 | cellular_component | lamellipodium |
| Y | 0032311 | cellular_component | angiogenin-PRI complex |
| Y | 0034315 | biological_process | regulation of Arp2/3 complex-mediated actin nucleation |
| Y | 0045765 | biological_process | regulation of angiogenesis |
| Y | 0070062 | cellular_component | extracellular exosome |
| Z | 0003676 | molecular_function | nucleic acid binding |
| Z | 0004519 | molecular_function | endonuclease activity |
| Z | 0004522 | molecular_function | ribonuclease A activity |
| Z | 0004540 | molecular_function | RNA nuclease activity |
| Z | 0005515 | molecular_function | protein binding |
| Z | 0005576 | cellular_component | extracellular region |
| Z | 0016829 | molecular_function | lyase activity |
| Z | 0050830 | biological_process | defense response to Gram-positive bacterium |
| Z | 0051607 | biological_process | defense response to virus |
| Z | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT X 900 |
| Chain | Residue |
| W | ASP435 |
| X | HOH952 |
| W | SER460 |
| W | HOH519 |
| X | ARG4 |
| X | LYS7 |
| X | GLN11 |
| X | LYS41 |
| X | VAL118 |
| X | HIS119 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF |
| Chain | Residue | Details |
| X | CYS40-PHE46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| W | SER1 | |
| Y | SER1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| W | THR81 | |
| Y | THR81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| W | SER90 | |
| Z | ARG85 | |
| Y | SER90 | |
| X | LYS41 | |
| X | LYS66 | |
| X | ARG85 | |
| Z | LYS7 | |
| Z | ARG10 | |
| Z | LYS41 | |
| Z | LYS66 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:3202829 |
| Chain | Residue | Details |
| X | ASN34 | |
| Z | ASN34 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3202829 |
| Chain | Residue | Details |
| X | ASN76 | |
| X | ASN88 | |
| Z | ASN76 | |
| Z | ASN88 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rbn |
| Chain | Residue | Details |
| X | PHE120 | |
| X | HIS119 | |
| X | HIS12 | |
| X | LYS41 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rbn |
| Chain | Residue | Details |
| Z | PHE120 | |
| Z | HIS119 | |
| Z | HIS12 | |
| Z | LYS41 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1rbn |
| Chain | Residue | Details |
| X | HIS119 | |
| X | HIS12 | |
| X | LYS41 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1rbn |
| Chain | Residue | Details |
| Z | HIS119 | |
| Z | HIS12 | |
| Z | LYS41 |
