2PYI

Crystal structure of Glycogen Phosphorylase in complex with glucosyl triazoleacetamide

Summary for 2PYI

• Entry DOI: 10.2210/pdb2pyi/pdb
• Related: 2PYD
• Descriptor: Glycogen phosphorylase, muscle form, N-[(4-PHENYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: glycogenolysis, inhibition, type 2 diabetes, transferase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 98796.20

Authors

Alexacou, K.M.,Tiraidis, C.,Zographos, S.E.,Chrysina, E.D.,Hayes, J.,Oikonomakos, N.G. (deposition date: 2007-05-16, release date: 2008-04-01, Last modification date: 2023-11-15)

• Primary citation: Alexacou, K.M.,Hayes, J.M.,Tiraidis, C.,Zographos, S.E.,Leonidas, D.D.,Chrysina, E.D.,Archontis, G.,Oikonomakos, N.G.,Paul, J.V.,Varghese, B.,Loganathan, D.; Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: Comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyranosyl urea binding.; Proteins, 71:1307-1323, 2007; PubMed: 18041758; DOI: 10.1002/prot.21837

Experimental method

X-RAY DIFFRACTION (1.88 Å)