2PVJ
Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2
Summary for 2PVJ
Entry DOI | 10.2210/pdb2pvj/pdb |
Related | 2PVH 2PVK 2PVL 2PVM 2PVN |
Descriptor | Casein kinase II subunit alpha, 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE (3 entities in total) |
Functional Keywords | structure-based drug design, enzyme-inhibitor complex, casein kinase ii, protein kinase ck2, transferase |
Biological source | Zea mays |
Total number of polymer chains | 1 |
Total formula weight | 41797.88 |
Authors | Nie, Z.,Perretta, C.,Erickson, P.,Margosiak, S.,Almassy, R.,Lu, J.,Averill, A.,Yager, K.M.,Chu, S. (deposition date: 2007-05-09, release date: 2008-05-13, Last modification date: 2021-10-20) |
Primary citation | Nie, Z.,Perretta, C.,Erickson, P.,Margosiak, S.,Almassy, R.,Lu, J.,Averill, A.,Yager, K.M.,Chu, S. Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2. Bioorg.Med.Chem.Lett., 17:4191-4195, 2007 Cited by PubMed: 17540560DOI: 10.1016/j.bmcl.2007.05.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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