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2PVK

Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2

Summary for 2PVK
Entry DOI10.2210/pdb2pvk/pdb
Related2PVH 2PVJ 2PVL 2PVM 2PVN
DescriptorCasein kinase II subunit alpha, 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE (3 entities in total)
Functional Keywordsstructure-based drug design, enzyme-inhibitor complex, casein kinase ii, protein kinase ck2, transferase
Biological sourceZea mays
Total number of polymer chains1
Total formula weight41826.28
Authors
Nie, Z.,Perretta, C.,Erickson, P.,Margosiak, S.,Almassy, R.,Lu, J.,Averill, A.,Yager, K.M.,Chu, S. (deposition date: 2007-05-09, release date: 2008-05-13, Last modification date: 2021-10-20)
Primary citationNie, Z.,Perretta, C.,Erickson, P.,Margosiak, S.,Almassy, R.,Lu, J.,Averill, A.,Yager, K.M.,Chu, S.
Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2.
Bioorg.Med.Chem.Lett., 17:4191-4195, 2007
Cited by
PubMed: 17540560
DOI: 10.1016/j.bmcl.2007.05.041
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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