2PMN

Crystal structure of PfPK7 in complex with an ATP-site inhibitor

Summary for 2PMN

Entry DOI	10.2210/pdb2pmn/pdb
Descriptor	Ser/Thr protein kinase, putative, 4-(6-{[(1S)-1-(HYDROXYMETHYL)-2-METHYLPROPYL]AMINO}IMIDAZO[1,2-B]PYRIDAZIN-3-YL)BENZONITRILE (3 entities in total)
Functional Keywords	ser/thr protein kinase; plasmodium falciparum; transferase; phosphorylation, transferase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	41755.97
Authors	Merckx, A.,Echalier, A.,Noble, M.,Endicott, J. (deposition date: 2007-04-23, release date: 2008-01-22, Last modification date: 2023-08-30)
Primary citation	Merckx, A.,Echalier, A.,Langford, K.,Sicard, A.,Langsley, G.,Joore, J.,Doerig, C.,Noble, M.,Endicott, J. Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design. Structure, 16:228-238, 2008 Cited by PubMed: 18275814 DOI: 10.1016/j.str.2007.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation