2PL0
LCK bound to imatinib
Summary for 2PL0
| Entry DOI | 10.2210/pdb2pl0/pdb |
| Descriptor | Proto-oncogene tyrosine-protein kinase LCK, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total) |
| Functional Keywords | kinase phosphorylation, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P06239 |
| Total number of polymer chains | 1 |
| Total formula weight | 33892.70 |
| Authors | Jacobs, M.D. (deposition date: 2007-04-18, release date: 2007-10-09, Last modification date: 2024-02-21) |
| Primary citation | Jacobs, M.D.,Caron, P.R.,Hare, B.J. Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex. Proteins, 70:1451-1460, 2007 Cited by PubMed: 17910071DOI: 10.1002/prot.21633 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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