2PJY

Structural basis for cooperative assembly of the TGF-beta signaling complex

2PJY の概要

• エントリーDOI: 10.2210/pdb2pjy/pdb
• 分子名称: Transforming growth factor beta-3, TGF-beta receptor type-2, TGF-beta receptor type-1, ... (4 entities in total)
• 機能のキーワード: ternary complex, three finger toxin, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P10600; Membrane; Single-pass type I membrane protein: P37173 P36897
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 33694.56

構造登録者

Groppe, J.,Zubieta, C. (登録日: 2007-04-16, 公開日: 2008-02-05, 最終更新日: 2023-08-30)

• 主引用文献: Groppe, J.,Hinck, C.S.,Samavarchi-Tehrani, P.,Zubieta, C.,Schuermann, J.P.,Taylor, A.B.,Schwarz, P.M.,Wrana, J.L.,Hinck, A.P.; Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.; Mol.Cell, 29:157-168, 2008; PubMed: 18243111; DOI: 10.1016/j.molcel.2007.11.039

実験手法

X-RAY DIFFRACTION (3 Å)