2PJB

CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[1-((S)-2-benzyloxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX

Summary for 2PJB

• Entry DOI: 10.2210/pdb2pjb/pdb
• Related: 1Z5R 1ZG7 1ZG8 1ZG9 2PIY 2PIZ 2PJ0 2PJ1 2PJ2 2PJ3 2PJ4 2PJ5 2PJ6 2PJ7 2PJ8 2PJ9 2PJA 2PJC
• Descriptor: Carboxypeptidase B, ZINC ION, (5S,9R,10R,12S)-12-[3-(AMINOMETHYL)PHENYL]-5-BENZYL-10-HYDROXY-9-ISOPROPYL-3-OXO-1-PHENYL-2-OXA-7-THIA-4,8-DIAZA-10-PHOSPHATRIDECAN-13-OIC ACID 7,7,10-TRIOXIDE, ... (4 entities in total)
• Functional Keywords: carboxypeptidase b, exopeptidase, phosphinate based inhibitor, hydrolase
• Biological source: Sus scrofa (pig)
• Cellular location: Secreted: P09955
• Total number of polymer chains: 3
• Total formula weight: 106352.91

Authors

Adler, M.,Whitlow, M. (deposition date: 2007-04-15, release date: 2008-01-22, Last modification date: 2023-08-30)

• Primary citation: Adler, M.,Buckman, B.,Bryant, J.,Chang, Z.,Chu, K.,Emayan, K.,Hrvatin, P.,Islam, I.,Morser, J.,Sukovich, D.,West, C.,Yuan, S.,Whitlow, M.; Structures of potent selective peptide mimetics bound to carboxypeptidase B.; Acta Crystallogr.,Sect.D, 64:149-157, 2008; PubMed: 18219114; DOI: 10.1107/S0907444907057228

Experimental method

X-RAY DIFFRACTION (1.7 Å)