2PGZ

Crystal structure of Cocaine bound to an ACh-Binding Protein

Summary for 2PGZ

Entry DOI	10.2210/pdb2pgz/pdb
Descriptor	Soluble acetylcholine receptor, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COCAINE, ... (6 entities in total)
Functional Keywords	non-competitive inhibitors, nicotinic acetycholine receptors, acetycholine-binding protein, benzodiazepine, galanthamine, cocaine, choline binding protein, choline-binding protein
Biological source	Aplysia californica (California sea hare)
Total number of polymer chains	5
Total formula weight	133381.94
Authors	Hansen, S.B.,Taylor, P. (deposition date: 2007-04-10, release date: 2007-07-03, Last modification date: 2023-08-30)
Primary citation	Hansen, S.B.,Taylor, P. Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors. J.Mol.Biol., 369:895-901, 2007 Cited by PubMed: 17481657 DOI: 10.1016/j.jmb.2007.03.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation