2PGZ
Crystal structure of Cocaine bound to an ACh-Binding Protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Soluble acetylcholine receptor | polymer | 230 | 26212.1 | 5 | UniProt (Q8WSF8) Pfam (PF02931) | Aplysia californica (California sea hare) | |
| 2 | F (F) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 3 | G, K (A, D) | COCAINE | non-polymer | 303.4 | 2 | Chemie (COC) | |||
| 4 | H (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | I, J, L (B, C, E) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) | |||
| 6 | M, N, O, P, Q (A, B, C, D, E) | water | water | 18.0 | 1141 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | cloning artifact |
| Tyr -7 | - | cloning artifact |
| Lys -6 | - | cloning artifact |
| Asp -5 | - | cloning artifact |
| Asp -4 | - | cloning artifact |
| Asp -3 | - | cloning artifact |
| Asp -2 | - | cloning artifact |
| Lys -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
| Ser 220 | - | cloning artifact |
| Arg 221 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131060.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1410.6 | |
| All* | Total formula weight | 133381.9 |
