2PGZ
Crystal structure of Cocaine bound to an ACh-Binding Protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Soluble acetylcholine receptor | polymer | 230 | 26212.1 | 5 | UniProt (Q8WSF8) | Aplysia californica (California sea hare) | |
| 2 | F (F) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 3 | G, K (A, D) | COCAINE | non-polymer | 303.4 | 2 | Chemie (COC) PubChem (2826) PubChem (5760) PubChem (44246523) PubChem (44281182) PubChem (44382114) PubChem (44382176) PubChem (44382277) PubChem (44382278) PubChem (122142) PubChem (135184) PubChem (50897619) PubChem (56840956) PubChem (165376) PubChem (44279116) PubChem (439497) PubChem (644005) PubChem (644017) PubChem (644018) PubChem (644271) PubChem (5872) PubChem (446220) PubChem (497304) PubChem (638023) PubChem (5315982) PubChem (6101676) PubChem (6338296) PubChem (6432459) PubChem (6432481) PubChem (98078900) PubChem (6918958) PubChem (9861246) PubChem (12305901) PubChem (10136514) PubChem (11779748) PubChem (13006129) PubChem (15558678) PubChem (15558680) PubChem (15558681) PubChem (15558688) PubChem (15558693) PubChem (124909386) PubChem (134972500) PubChem (173815154) | |||
| 4 | H (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | I, J, L (B, C, E) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 3 | Chemie (PG4) PubChem (8200) | |||
| 6 | M, N, O, P, Q (A, B, C, D, E) | water | water | 18.0 | 1141 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | cloning artifact |
| Tyr -7 | - | cloning artifact |
| Lys -6 | - | cloning artifact |
| Asp -5 | - | cloning artifact |
| Asp -4 | - | cloning artifact |
| Asp -3 | - | cloning artifact |
| Asp -2 | - | cloning artifact |
| Lys -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
| Ser 220 | - | cloning artifact |
| Arg 221 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131060.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1410.6 | |
| All* | Total formula weight | 133381.9 |
