2PE0
CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX
Summary for 2PE0
Entry DOI | 10.2210/pdb2pe0/pdb |
Related | 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1Z5M 2PE1 2PE2 |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, SULFATE ION, 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE, ... (5 entities in total) |
Functional Keywords | protein inhibitor complex, serine kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 33838.78 |
Authors | Whitlow, M.,Adler, M. (deposition date: 2007-04-01, release date: 2007-06-12, Last modification date: 2011-07-13) |
Primary citation | Islam, I.,Bryant, J.,Chou, Y.L.,Kochanny, M.J.,Lee, W.,Phillips, G.B.,Yu, H.,Adler, M.,Whitlow, M.,Ho, E.,Lentz, D.,Polokoff, M.A.,Subramanyam, B.,Wu, J.M.,Zhu, D.,Feldman, R.I.,Arnaiz, D.O. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity. Bioorg.Med.Chem.Lett., 17:3814-3818, 2007 Cited by PubMed: 17531483DOI: 10.1016/j.bmcl.2007.04.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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