2P86

The high resolution crystal structure of rhodesain, the major cathepsin L protease from T. brucei rhodesiense, bound to inhibitor K11002

2P86 の概要

• エントリーDOI: 10.2210/pdb2p86/pdb
• 関連するPDBエントリー: 2P7U
• 分子名称: Cysteine protease, 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: cysteine protease, trypanosoma brucei, neglected disease, hydrolase
• 由来する生物種: Trypanosoma brucei rhodesiense
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24149.64

構造登録者

Brinen, L.S.,Marion, R. (登録日: 2007-03-21, 公開日: 2008-04-01, 最終更新日: 2023-08-30)

• 主引用文献: Marion, R.,Hansell, E.,Caffrey, C.,Roush, W.R.,Brinen, L.S.; THE high resolution structure of rhodesain, the major cathepsin L protease from trypanosoma brucei rhodesiense, illustrates the basis for differences in inhibition profiles from other papain family cysteine proteases; To be Published,

実験手法

X-RAY DIFFRACTION (1.16 Å)