2P7U

The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777

Summary for 2P7U

Entry DOI	10.2210/pdb2p7u/pdb
Descriptor	Cysteine protease, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE (3 entities in total)
Functional Keywords	cysteine protease, trypanosoma brucei, neglected disease, hydrolase
Biological source	Trypanosoma brucei rhodesiense
Total number of polymer chains	1
Total formula weight	23479.94
Authors	Brinen, L.S.,Marion, R. (deposition date: 2007-03-20, release date: 2008-03-25, Last modification date: 2023-08-30)
Primary citation	Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J.Biol.Chem., 284:25697-25703, 2009 Cited by PubMed: 19620707 DOI: 10.1074/jbc.M109.014340 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation