2P7U
The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cysteine protease | polymer | 215 | 22903.2 | 1 | UniProt (Q95PM0) Pfam (PF00112) | Trypanosoma brucei rhodesiense | |
| 2 | B (A) | NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE | non-polymer | 576.7 | 1 | Chemie (D1R) | |||
| 3 | C (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 1 - 215 (UniProt: Q95PM0)
| PDB | External Database | Details |
|---|---|---|
| Ala 172 | Ser 297 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22903.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 576.7 | |
| All* | Total formula weight | 23479.9 |
