2P4T

Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode

Summary for 2P4T

• Entry DOI: 10.2210/pdb2p4t/pdb
• Related: 1VIE 1VIF 2GQV
• Descriptor: Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• Functional Keywords: bacterial infections, folate metabolism, nadp+, r67 dhfr, symmetric binding, trimethoprim-resistance, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 7485.95

Authors

Divya, N.,Grifith, E.,Narayana, N. (deposition date: 2007-03-13, release date: 2007-06-05, Last modification date: 2023-08-30)

• Primary citation: Divya, N.,Grifith, E.,Narayana, N.; Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.; Protein Sci., 16:1063-1068, 2007; PubMed: 17473013; DOI: 10.1110/ps.062740907

Experimental method

X-RAY DIFFRACTION (1.15 Å)