2P4T

Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode

2P4T の概要

• エントリーDOI: 10.2210/pdb2p4t/pdb
• 関連するPDBエントリー: 1VIE 1VIF 2GQV
• 分子名称: Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: bacterial infections, folate metabolism, nadp+, r67 dhfr, symmetric binding, trimethoprim-resistance, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7485.95

構造登録者

Divya, N.,Grifith, E.,Narayana, N. (登録日: 2007-03-13, 公開日: 2007-06-05, 最終更新日: 2023-08-30)

• 主引用文献: Divya, N.,Grifith, E.,Narayana, N.; Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.; Protein Sci., 16:1063-1068, 2007; PubMed: 17473013; DOI: 10.1110/ps.062740907

実験手法

X-RAY DIFFRACTION (1.15 Å)