2P4A
X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A
Summary for 2P4A
Entry DOI | 10.2210/pdb2p4a/pdb |
Descriptor | Ribonuclease pancreatic, ANTIBODY CAB-RN05, SULFATE ION, ... (4 entities in total) |
Functional Keywords | camelid single-domain antibody, vhh, cab-rn05, rnase a, paratope, yeast surface display, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Camelus dromedarius (Arabian camel) More |
Cellular location | Secreted: P61823 |
Total number of polymer chains | 4 |
Total formula weight | 53269.33 |
Authors | Tereshko, V.,Koide, A.,Uysal, S.,Koide, S. (deposition date: 2007-03-11, release date: 2007-08-28, Last modification date: 2023-08-30) |
Primary citation | Koide, A.,Tereshko, V.,Uysal, S.,Margalef, K.,Kossiakoff, A.A.,Koide, S. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J.Mol.Biol., 373:941-953, 2007 Cited by PubMed: 17888451DOI: 10.1016/j.jmb.2007.08.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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