2P16
Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE
Summary for 2P16
Entry DOI | 10.2210/pdb2p16/pdb |
Descriptor | Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor), CALCIUM ION, 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ... (5 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32535.91 |
Authors | Alexander, R. (deposition date: 2007-03-02, release date: 2007-10-16, Last modification date: 2023-08-30) |
Primary citation | Pinto, D.J.,Orwat, M.J.,Koch, S.,Rossi, K.A.,Alexander, R.S.,Smallwood, A.,Wong, P.C.,Rendina, A.R.,Luettgen, J.M.,Knabb, R.M.,He, K.,Xin, B.,Wexler, R.R.,Lam, P.Y. Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa. J.Med.Chem., 50:5339-5356, 2007 Cited by PubMed: 17914785DOI: 10.1021/jm070245n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report