2P16

Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE

Summary for 2P16

• Entry DOI: 10.2210/pdb2p16/pdb
• Descriptor: Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor), CALCIUM ION, 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ... (5 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32535.91

Authors

Alexander, R. (deposition date: 2007-03-02, release date: 2007-10-16, Last modification date: 2023-08-30)

• Primary citation: Pinto, D.J.,Orwat, M.J.,Koch, S.,Rossi, K.A.,Alexander, R.S.,Smallwood, A.,Wong, P.C.,Rendina, A.R.,Luettgen, J.M.,Knabb, R.M.,He, K.,Xin, B.,Wexler, R.R.,Lam, P.Y.; Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.; J.Med.Chem., 50:5339-5356, 2007; PubMed: 17914785; DOI: 10.1021/jm070245n

Experimental method

X-RAY DIFFRACTION (2.3 Å)