2OZ7

Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate

2OZ7 の概要

• エントリーDOI: 10.2210/pdb2oz7/pdb
• 関連するPDBエントリー: 1i38 1z95 2ax6 2ax7 2axa
• 分子名称: Androgen receptor, CYPROTERONE ACETATE (3 entities in total)
• 機能のキーワード: androgen receptor, anti-androgen, prostate cancer, hormone receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29432.99

構造登録者

Bohl, C.E.,Wu, Z.,Miller, D.D.,Bell, C.E.,Dalton, J.T. (登録日: 2007-02-25, 公開日: 2007-03-27, 最終更新日: 2023-08-30)

• 主引用文献: Bohl, C.E.,Wu, Z.,Miller, D.D.,Bell, C.E.,Dalton, J.T.; Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.; J.Biol.Chem., 282:13648-13655, 2007; PubMed: 17311914; DOI: 10.1074/jbc.M611711200

実験手法

X-RAY DIFFRACTION (1.8 Å)