2OZ5

Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS

2OZ5 の概要

• エントリーDOI: 10.2210/pdb2oz5/pdb
• 分子名称: Phosphotyrosine protein phosphatase ptpb, {(3-CHLOROBENZYL)[(5-{[(3,3-DIPHENYLPROPYL)AMINO]SULFONYL}-2-THIENYL)METHYL]AMINO}(OXO)ACETIC ACID (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase in complex with small molecule inhibitor, structural genomics, tb structural genomics consortium, tbsgc, unknown function
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67062.85

構造登録者

Grundner, C.,Gee, C.L.,Alber, T.,TB Structural Genomics Consortium (TBSGC) (登録日: 2007-02-23, 公開日: 2007-05-01, 最終更新日: 2024-02-21)

• 主引用文献: Grundner, C.,Perrin, D.,Hooft van Huijsduijnen, R.,Swinnen, D.,Gonzalez, J.,Gee, C.L.,Wells, T.N.,Alber, T.; Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB.; Structure, 15:499-509, 2007; PubMed: 17437721; DOI: 10.1016/j.str.2007.03.003

実験手法

X-RAY DIFFRACTION (2 Å)