2OW1
MMP-9 active site mutant with trifluoromethyl hydroxamate inhibitor
Summary for 2OW1
Entry DOI | 10.2210/pdb2ow1/pdb |
Related | 1GKC 1GKD |
Descriptor | Matrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB), ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | matrix metalloproteinase, s1-prime pocket, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space, extracellular matrix : P14780 |
Total number of polymer chains | 2 |
Total formula weight | 37248.98 |
Authors | Tochowicz, A.,Bode, W.,Maskos, K.,Goettig, P. (deposition date: 2007-02-15, release date: 2007-06-19, Last modification date: 2024-02-21) |
Primary citation | Tochowicz, A.,Maskos, K.,Huber, R.,Oltenfreiter, R.,Dive, V.,Yiotakis, A.,Zanda, M.,Bode, W.,Goettig, P. Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity. J.Mol.Biol., 371:989-1006, 2007 Cited by PubMed: 17599356DOI: 10.1016/j.jmb.2007.05.068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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