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2OW1

MMP-9 active site mutant with trifluoromethyl hydroxamate inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BMatrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB)polymer15917875.82UniProt (P14780)
Pfam (PF00413)
In PDB
Homo sapiens (human)
2A, BZINC IONnon-polymer65.44Chemie (ZN)
3A, BCALCIUM IONnon-polymer40.18Chemie (CA)
4ACHLORIDE IONnon-polymer35.53Chemie (CL)
5A, B(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDEnon-polymer404.42Chemie (7MR)
6waterwater18.0209Chemie (HOH)
Sequence modifications
A, B: 110 - 215 (UniProt: P14780)
A, B: 391 - 443 (UniProt: P14780)
PDBExternal DatabaseDetails
Gln 402Glu 402engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight35751.6
Non-Polymers*Number of molecules17
Total formula weight1497.3
All*Total formula weight37249.0
*Water molecules are not included.

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PDB entries from 2024-06-12

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