2OW1
MMP-9 active site mutant with trifluoromethyl hydroxamate inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Matrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) | polymer | 159 | 17875.8 | 2 | UniProt (P14780) Pfam (PF00413) In PDB | Homo sapiens (human) | |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | A, B | (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE | non-polymer | 404.4 | 2 | Chemie (7MR) | |||
| 6 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 110 - 215 (UniProt: P14780)
A, B: 391 - 443 (UniProt: P14780)
A, B: 391 - 443 (UniProt: P14780)
| PDB | External Database | Details |
|---|---|---|
| Gln 402 | Glu 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35751.6 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1497.3 | |
| All* | Total formula weight | 37249.0 |
