2ORP

Murine inducible nitric oxide synthase oxygenase domain (delta 114) 2-[4-(2-Imidazol-1-yl-6-methyl-pyrimidin-4-yl)-1-isobutyryl-piperazin-2-yl]-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide complex

Summary for 2ORP

• Entry DOI: 10.2210/pdb2orp/pdb
• Related: 1DD7 1NOC 1NOD 1NOS 1NSI 2NOS 2ORO 2ORQ 2ORR 2ORS 2ORT
• Descriptor: nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 2-{(2R)-4-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-1-ISOBUTYRYLPIPERAZIN-2-YL}-N-[2-(4-METHOXYPHENYL)ETHYL]ACETAMIDE, ... (4 entities in total)
• Functional Keywords: nitric oxide; l-arginine monooxygenase; heme; dimerization; inhibitor; nos, oxidoreductase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 46392.48

Authors

Adler, M.,Whitlow, M. (deposition date: 2007-02-04, release date: 2007-04-10, Last modification date: 2023-08-30)

• Primary citation: Davey, D.D.,Adler, M.,Arnaiz, D.,Eagen, K.,Erickson, S.,Guilford, W.,Kenrick, M.,Morrissey, M.M.,Ohlmeyer, M.,Pan, G.,Paradkar, V.M.,Parkinson, J.,Polokoff, M.,Saionz, K.,Santos, C.,Subramanyam, B.,Vergona, R.,Wei, R.G.,Whitlow, M.,Ye, B.,Zhao, Z.S.,Devlin, J.J.,Phillips, G.; Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors; J.Med.Chem., 50:1146-1157, 2007; PubMed: 17315988; DOI: 10.1021/jm061319i

Experimental method

X-RAY DIFFRACTION (1.97 Å)