2ONY

Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy

Summary for 2ONY

Entry DOI	10.2210/pdb2ony/pdb
Related	1HNN 2G8N 2ONZ
Descriptor	Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, ... (5 entities in total)
Functional Keywords	methyltransferase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	64878.54
Authors	Drinkwater, N.,Martin, J.L. (deposition date: 2007-01-24, release date: 2007-10-09, Last modification date: 2023-10-25)
Primary citation	Gee, C.L.,Drinkwater, N.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50:4845-4853, 2007 Cited by PubMed: 17845018 DOI: 10.1021/jm0703385 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation