2OKK

The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65)

Summary for 2OKK

Entry DOI	10.2210/pdb2okk/pdb
Related	2OKJ
Descriptor	Glutamate decarboxylase 2, GAMMA-AMINO-BUTANOIC ACID, GLYCEROL, ... (4 entities in total)
Functional Keywords	plp-dependent decarboxylase, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol: Q05329
Total number of polymer chains	1
Total formula weight	57080.66
Authors	Buckle, A.M.,Fenalti, G.,Law, R.H.P.,Whisstock, J.C. (deposition date: 2007-01-17, release date: 2007-03-27, Last modification date: 2023-11-15)
Primary citation	Fenalti, G.,Law, R.H.,Buckle, A.M.,Langendorf, C.,Tuck, K.,Rosado, C.J.,Faux, N.G.,Mahmood, K.,Hampe, C.S.,Banga, J.P.,Wilce, M.,Schmidberger, J.,Rossjohn, J.,El-Kabbani, O.,Pike, R.N.,Smith, A.I.,Mackay, I.R.,Rowley, M.J.,Whisstock, J.C. GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat.Struct.Mol.Biol., 14:280-286, 2007 Cited by PubMed: 17384644 DOI: 10.1038/nsmb1228 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation