Crystal Structure of the UDP-Glucuronic Acid Binding Domain of the Human Drug Metabolizing UDP-Glucuronosyltransferase 2B7

Summary for 2O6L

DescriptorUDP-glucuronosyltransferase 2B7 (2 entities in total)
Functional Keywordsdrug metabolism, rossman, mad, enzyme, nucleotide binding, sugar, udp-glucuronosyltransferase, ugt, transferase
Biological sourceHomo sapiens (human)
Cellular locationMicrosome membrane; Single-pass membrane protein (Potential) P16662
Total number of polymer chains2
Total molecular weight38251.44
Miley, M.J.,Redinbo, M.R. (deposition date: 2006-12-07, release date: 2007-05-01, Last modification date: 2011-07-13)
Primary citation
Miley, M.J.,Zielinska, A.K.,Keenan, J.E.,Bratton, S.M.,Radominska-Pandya, A.,Redinbo, M.R.
Crystal Structure of the Cofactor-Binding Domain of the Human Phase II Drug-Metabolism Enzyme UDP-Glucuronosyltransferase 2B7.
J.Mol.Biol., 369:498-511, 2007
PubMed: 17442341 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.03.066
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2491102.5%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution