2O27

Structure of a class III RTK signaling assembly

Summary for 2O27

• Entry DOI: 10.2210/pdb2o27/pdb
• Related: 2O26
• Descriptor: Kit ligand (2 entities in total)
• Functional Keywords: stem cell factor, receptor tyrosine kinase, class iii, receptor-ligand complex, growth factor, cytokine, 4-helix bundle, signaling protein
• Biological source: Mus musculus (house mouse)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (By similarity). Isoform 2: Cell membrane; Single-pass type I membrane protein (By similarity). Soluble KIT ligand: Secreted (By similarity): P20826
• Total number of polymer chains: 2
• Total formula weight: 32889.53

Authors

Liu, H.,Chen, X.,Focia, P.,He, X. (deposition date: 2006-11-29, release date: 2007-03-13, Last modification date: 2023-08-30)

• Primary citation: Liu, H.,Chen, X.,Focia, P.J.,He, X.; Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.; Embo J., 26:891-901, 2007; PubMed: 17255936; DOI: 10.1038/sj.emboj.7601545

Experimental method

X-RAY DIFFRACTION (2.2 Å)