Summary for 2NYR
| Entry DOI | 10.2210/pdb2nyr/pdb |
| Descriptor | NAD-dependent deacetylase sirtuin-5, ZINC ION, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, ... (4 entities in total) |
| Functional Keywords | histone deacetylase, structural genomics, structural genomics consortium, sgc, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion matrix: Q9NXA8 |
| Total number of polymer chains | 2 |
| Total formula weight | 60281.14 |
| Authors | Min, J.R.,Antoshenko, T.,Allali-Hassani, A.,Dong, A.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Plotnikov, A.N.,Structural Genomics Consortium (SGC) (deposition date: 2006-11-21, release date: 2006-12-19, Last modification date: 2023-08-30) |
| Primary citation | Schuetz, A.,Min, J.,Antoshenko, T.,Wang, C.L.,Allali-Hassani, A.,Dong, A.,Loppnau, P.,Vedadi, M.,Bochkarev, A.,Sternglanz, R.,Plotnikov, A.N. Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure, 15:377-389, 2007 Cited by PubMed: 17355872DOI: 10.1016/j.str.2007.02.002 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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