2NW8

Crystal Structure of Tryptophan 2,3-dioxygenase (TDO) from Xanthomonas campestris in complex with ferrous heme and tryptophan. Northeast Structural Genomics Target XcR13.

Summary for 2NW8

• Entry DOI: 10.2210/pdb2nw8/pdb
• Related: 1YW0 1ZEE 2NW7 2NW9 2NWB
• Descriptor: Tryptophan 2,3-dioxygenase, TRYPTOPHAN, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• Functional Keywords: all alpha-helical protein, structural genomics, psi-2, protein structure initiative, northeast structural genomics consortium, nesg, oxidoreductase
• Biological source: Xanthomonas campestris pv. campestris
• Total number of polymer chains: 2
• Total formula weight: 73622.59

Authors

Forouhar, F.,Anderson, J.L.R.,Mowat, C.G.,Bruckmann, C.,Thackray, S.J.,Seetharaman, J.,Ho, C.K.,Ma, L.C.,Cunningham, K.,Janjua, H.,Zhao, L.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Champman, S.K.,Tong, L.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2006-11-14, release date: 2006-12-19, Last modification date: 2023-08-30)

• Primary citation: Forouhar, F.,Anderson, J.L.,Mowat, C.G.,Vorobiev, S.M.,Hussain, A.,Abashidze, M.,Bruckmann, C.,Thackray, S.J.,Seetharaman, J.,Tucker, T.,Xiao, R.,Ma, L.C.,Zhao, L.,Acton, T.B.,Montelione, G.T.,Chapman, S.K.,Tong, L.; Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.; Proc.Natl.Acad.Sci.Usa, 104:473-478, 2007; PubMed: 17197414; DOI: 10.1073/pnas.0610007104

Experimental method

X-RAY DIFFRACTION (1.6 Å)