2NVU

Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex

2NVU の概要

分子名称NEDD8-activating enzyme E1 regulatory subunit, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, NEDD8-conjugating enzyme Ubc12, ... (8 entities in total)
機能のキーワードmultifunction macromolecular complex, ubiquitin, nedd8, e1, e2, atp, conformational change, thioester, switch, adenylation, protein turnover, ligase
由来する生物種Homo sapiens (human)
細胞内の位置Cell membrane Q13564
Nucleus Q15843
ポリマー鎖数5
分子量合計188893.13
構造登録者
Huang, D.T.,Hunt, H.W.,Zhuang, M.,Ohi, M.D.,Holton, J.M.,Schulman, B.A. (登録日: 2006-11-13, 公開日: 2007-01-30, 最終更新日: 2011-07-13)
主引用文献
Huang, D.T.,Hunt, H.W.,Zhuang, M.,Ohi, M.D.,Holton, J.M.,Schulman, B.A.
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445:394-398, 2007
PubMed: 17220875 (主引用文献が同じPDBエントリー)
DOI: 10.1038/nature05490
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.8 Å)
NMR情報
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.237211.2%5.6%12.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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