2NT7
Crystal structure of PTP1B-inhibitor complex
Summary for 2NT7
Entry DOI | 10.2210/pdb2nt7/pdb |
Related | 2H4G 2H4K 2HCE 2HCW 2HCX 2HFA 2NTA |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, {[5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-2-(2H-TETRAZOL-5-YL)-3-THIENYL]OXY}ACETIC ACID (3 entities in total) |
Functional Keywords | ptp1b, protein-inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35453.23 |
Authors | Xu, W.,Follows, B. (deposition date: 2006-11-07, release date: 2007-04-17, Last modification date: 2023-12-27) |
Primary citation | Wan, Z.K.,Follows, B.,Kirincich, S.,Wilson, D.,Binnun, E.,Xu, W.,Joseph-McCarthy, D.,Wu, J.,Smith, M.,Zhang, Y.L.,Tam, M.,Erbe, D.,Tam, S.,Saiah, E.,Lee, J. Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17:2913-2920, 2007 Cited by PubMed: 17336064DOI: 10.1016/j.bmcl.2007.02.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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